B100 with Nature's Aid brand made my under-eye bags worse when 100-200 mg of B1 was added. They may also have been worse with 2000 mcg adenocobalamin or 2000 mcg methylcobalamin.

Biotin topically made my hair soft but seemed to make hair growth from topical castor oil no longer occur.

Vitamin B1 was only used for 3 days, but it seemed to stop B12 from making me warm and stop biotin from filling my penis with fluid. Took 2000mg, same as B12.

Calcium Alpha-Ketoglutarate (CA AKG) seemed to make my brain feel tired and sleepy. Possibly I was not getting enough glucose.