B100 with Nature's Aid brand made my under-eye bags worse when 100-200 mg of B1 was added. They may also have been worse with 2000 mcg adenocobalamin or 2000 mcg methylcobalamin.

Vitamin B1 was only used for 3 days, but it seemed to stop B12 from making me warm and stop biotin from filling my penis with fluid. Took 2000mg, same as B12.

Calcium Alpha-Ketoglutarate (CA AKG) seemed to make my brain feel tired and sleepy. Possibly I was not getting enough glucose.

NAC and glycine seem to make me sleep well and feel refreshed. Together they continued healing a facial dimple where NAD stopped. 600 mg was good; more, up to 2400 mg, made my face puffy and caused pressure in my head. Large amounts seemed to stop the muscle-building effects of B12. The combination helped my body keep going after a hard day's work. When I used NAC without glycine, I became weak and had difficulty walking uphill.